Rhamnose-based glycomimetic for recruitment of endogenous anti-rhamnose antibodies

Recruitment of natural antibodies towards tumour cells for their elimination by the immune system could be a highly specific and efficacious therapeutic strategy. While l-rhamnose has already been explored as suitable antigen antibody recruitment, we here report first rhamnose-based glycomimetic to used such purpose. The is designed more hydrolytically enzymatically stable than rhamnosides, provides site easy further conjugation proved capture anti-rhamnose IgG in serological ELISA assay.